Van de Ven Brace Halts The Toffees' Unbeaten Streak at New Home Ground
The Dutch defender became the initial backline player to net twice in a English top-flight match for Tottenham since Jan Vertonghen in March 2013.
Match summary
Micky Van de Ven heads into the net two times in opening period
The home side's Jake O'Brien has goal disallowed after VAR review
Pape Matar Sarr scores final goal in 89th minute
The defeat is Everton's initial at their new ground
Micky van de Ven found the net twice as Tottenham prolonged their winning streak on the road in the top division and handed the Toffees their first defeat at their new home.
Everton were undefeated in their last five matches at their recently opened stadium at the dockside location, having departed Goodison Park behind after 133 years at the conclusion of the previous campaign.
But Spurs captain Van de Ven pounced twice from corners in the first half to put their impressive record at jeopardy, and they were failed to mount a comeback before the midfielder - assisted by former Toffees attacker the Brazilian - headed home a final goal to put the game to bed.
Jake O'Brien believed he had levelled the tally a short while after the defender's opener, glancing a bullet header past Guglielmo Vicario from an Everton corner.
Beto, in the meantime, failed to convert a number of chances, while Vicario made a succession of fine stops to ensure Tottenham went five away games unbeaten in the English top flight.
But the VAR stepped in, instructing the match official to check the goal on the pitchside monitor and the official ruled that Jack Grealish and Iliman Ndiaye were in an illegal position and had impeded with the Spurs keeper.
The win moves the manager's team into third place in the Premier League, a handful of points off local foes and table-toppers the Gunners.
Everton remain 14th and are half a dozen points clear of the relegation zone.
Tottenham analysis: Van de Ven excels in duties at each end of the field
After a uninspiring weekday performance in the Champions League against the French side, where they mustered a mere two shots on goal, Frank chose the French striker in attack instead of former Toffees player Richarlison.
The new arrival was failed to influence the game before being replaced for Richarlison after 60 minutes on the pitch, but it emerged he wasn't needed in the end.
Defender Van de Ven transformed into an attacking force to be feared.
Spurs' first goal came from a cleverly executed set-piece play, with the midfielder heading the ball toward the face of goal for an unmarked Van de Ven to head home.
And the captain - filling in as skipper in the Argentine's absence - notched his second in added time as he rose above Jordan Pickford to nod in.
The Dutchman was equally impressive in defence, partnering effectively with his defensive colleague as the duo handled superbly with the numerous deliveries thrown their way by Everton.
Everton analysis: Everton missing striker's instinct
The club's new home had been a fortress, but it seems the novelty may have worn off slightly and supporters headed to the exits after the midfielder's third for Spurs.
The break in Everton's unbeaten home run won't be a massive worry for the manager, but their attacking woes are.
Beto and Thierno Barry - the Everton's two established strikers - had netted just a single goal between them before Sunday's match.
And they were unable to add to that miserable tally on a damp and dreary night on Merseyside.
The striker's form was summed up when he chose to overhead kick a clear chance from near the goal, even with having space and time to reposition for a simpler shot that would have challenged the keeper.
The substitute, too, failed to influence the game after replacing Beto in the second half.
It was not for a lack of opportunity. The majority of Everton's attacks came through the winger and Ndiaye, who tirelessly delivered dangerous crosses into the Spurs box.
Upcoming fixtures for both teams?
The Toffees: Moyes' men travel to Sunderland in the top flight on Monday, 3 November at 20:00 GMT.
Spurs: The London club go to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup tie against Newcastle.